Annexin A1 alleviates heatstroke by inhibiting RIPK3/MLKL‐mediated necroptosis through an FPR2‐dependent pathway in male mice

Key Points

This study aims to investigate the role of Annexin A1 in mitigating heatstroke and its underlying mechanisms.
Measured AnxA1 levels in heatstroke patients and mice models.
Compared heatstroke severity between wild-type and AnxA1/FPR2-deficient mice.
Administered recombinant AnxA1 in vivo and in vitro to evaluate therapeutic potential and mechanisms.
AnxA1 levels increased significantly in response to heat stress in both patients and mice.
Absence of AnxA1 or FPR2 worsened heatstroke symptoms while AnxA1 administration improved them.
AnxA1 treatment inhibited the phosphorylation of RIPK3 and MLKL, key proteins in necroptosis.

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Shows Annexin A1 alleviates heatstroke in male mice, suggesting potential therapeutic strategies.

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Feng et al. (2026) studied this question.

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