What question did this study set out to answer?

To evaluate whether a wirelessly powered subretinal neuroprosthetic implant can substitute for lost photoreceptors and restore functional vision in patients blinded by hereditary retinal degenerations.

February 20, 2013Proceedings of the Royal Society B Biological SciencesOpen Access

Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS

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Authors

KŠKatarína ŠtinglSTZ eyetrial KBKarl Ulrich Bartz‐SchmidtUniversity of Bonn DBDorothea BeschUniversitäts-Augenklinik Bonn

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Overview

Clinical trial demonstrates restored visual perception and object recognition in blind patients, indicating the functional efficacy of wireless subretinal neuroprostheses.

Key Points

To evaluate whether a wirelessly powered subretinal neuroprosthetic implant can substitute for lost photoreceptors and restore functional vision in patients blinded by hereditary retinal degenerations.
Subretinally implanted a 9 mm² microelectronic chip containing 1,500 independent microphotodiode-amplifier-electrode elements into 9 blind patients (N=9).
Powered the device wirelessly through transdermal inductive transmission and assessed visual functions repeatedly over a 9-month follow-up period, using powered-off states as controls.
Restored light perception in 8/9 patients, light localization in 7/9, motion detection up to 35 deg s⁻¹ in 5/9, grating acuity up to 3.3 cycles/degree in 6/9, and Landolt C-ring visual acuity up to 20/546 (1.43 logMAR) in 2/9.
Identification, localization, and discrimination of objects improved significantly across repeated evaluations over 9 months (n=8; p < 0.05 for each subtest).
Three subjects read letters spontaneously (and one following training), with 5/9 reporting implant-mediated visual perception in daily life over a 15° visual field.

Cite This Study

Štingl et al. (2013) studied this question.

synapsesocial.com/papers/69fc4651fb087793c078d6b7 https://doi.org/10.1098/rspb.2013.0077

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February 20, 2013Proceedings of the Royal Society B Biological SciencesOpen Access

Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS

View Full Paper

Ask AI

Bookmark

Authors

KŠKatarína ŠtinglSTZ eyetrial KBKarl Ulrich Bartz‐SchmidtUniversity of Bonn DBDorothea BeschUniversitäts-Augenklinik Bonn

Discussion

Member takes

Overview

Clinical trial demonstrates restored visual perception and object recognition in blind patients, indicating the functional efficacy of wireless subretinal neuroprostheses.

Key Points

To evaluate whether a wirelessly powered subretinal neuroprosthetic implant can substitute for lost photoreceptors and restore functional vision in patients blinded by hereditary retinal degenerations.
Subretinally implanted a 9 mm² microelectronic chip containing 1,500 independent microphotodiode-amplifier-electrode elements into 9 blind patients (N=9).
Powered the device wirelessly through transdermal inductive transmission and assessed visual functions repeatedly over a 9-month follow-up period, using powered-off states as controls.
Restored light perception in 8/9 patients, light localization in 7/9, motion detection up to 35 deg s⁻¹ in 5/9, grating acuity up to 3.3 cycles/degree in 6/9, and Landolt C-ring visual acuity up to 20/546 (1.43 logMAR) in 2/9.
Identification, localization, and discrimination of objects improved significantly across repeated evaluations over 9 months (n=8; p < 0.05 for each subtest).
Three subjects read letters spontaneously (and one following training), with 5/9 reporting implant-mediated visual perception in daily life over a 15° visual field.

Cite This Study

Štingl et al. (2013) studied this question.

synapsesocial.com/papers/69fc4651fb087793c078d6b7 https://doi.org/10.1098/rspb.2013.0077

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