What question did this study set out to answer?

Evaluate the therapeutic efficacy, dosing requirements, and potential toxicity of intravenous lidocaine for managing ventricular arrhythmias after myocardial infarction.

December 7, 1967New England Journal of Medicine

Effect of Lidocaine on Ventricular Arrhythmias in Patients with Coronary Heart Disease

View Full Paper

Ask AI

Bookmark

Why the study?

Does lidocaine suppress ventricular arrhythmias in patients with coronary heart disease and acute myocardial infarction?

Population

Patients with coronary heart disease, particularly those with acute myocardial infarction and ventricular…

Design

Other

Authors

RGRalph E. GianellyTufts University JGJ. O. von der GroebenStanford University ASAlfred P. SpivackSorbonne Université

Discussion

Member takes

Implication

Supports lidocaine for suppressing ventricular arrhythmias in acute MI; extends case reports with RCT evidence.

Key Points

Evaluate the therapeutic efficacy, dosing requirements, and potential toxicity of intravenous lidocaine for managing ventricular arrhythmias after myocardial infarction.
Assessed intravenous lidocaine administered via bolus injection or continuous infusion.
Observed antiarrhythmic responses in patients experiencing ventricular tachycardia and frequent ventricular extrasystoles associated with coronary heart disease.
Intravenous administration of lidocaine consistently terminates episodes of ventricular tachycardia.
Lidocaine suppresses multiple ventricular extrasystoles, though precise therapeutic ranges must be balanced against systemic toxicity.

Structured PICO

Does lidocaine suppress ventricular arrhythmias in patients with coronary heart disease and acute myocardial infarction?

Population

Patients with coronary heart disease, particularly those with acute myocardial infarction and ventricular arrhythmias

Intervention

Lidocaine (intravenous bolus or constant intravenous infusion)

Outcome

Effect on ventricular arrhythmias (ventricular tachycardia, ventricular extrasystoles)

This paper discusses the evaluation of lidocaine for treating ventricular arrhythmias in patients with myocardial infarction.

Cite This Study

Gianelly et al. (1967) studied this question.

synapsesocial.com/papers/69fcc75a07e58738e9dd9e4f https://doi.org/10.1056/nejm196712072772301

View Full Paper

Ask AI

Bookmark

Effect of Lidocaine on Ventricular Arrhythmias in Patients with Coronary Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of Lidocaine on Ventricular Arrhythmias in Patients with Coronary Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider