What question did this study set out to answer?

Synthesize evidence on ligand-induced reactive oxygen species generation, their cellular sources, and the molecular mechanisms governing physiological signal transduction and pathological oxidative stress.

December 1, 2000AJP Lung Cellular and Molecular Physiology

Reactive oxygen species in cell signaling

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Authors

VTVictor J. ThannickalTulane University BFBarry L. FanburgVascular / Pulmonary Vascular

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Implication

Narrative review demonstrates dual roles of reactive oxygen species in physiological signaling and macromolecular damage, highlighting targeted redox mechanisms in disease pathogenesis.

Key Points

Synthesize evidence on ligand-induced reactive oxygen species generation, their cellular sources, and the molecular mechanisms governing physiological signal transduction and pathological oxidative stress.
Reviewed experimental literature evaluating mitochondrial reactive oxygen species formation and specialized plasma membrane oxidase activation.
Assessed molecular evidence regarding growth factor- and cytokine-induced oxidative signaling across physiological and pathological contexts.
Excessive reactive oxygen species generation overwhelms cellular antioxidant defenses, inducing oxidative stress and damaging macromolecules including lipids, proteins, and DNA implicated in lung diseases.
Specialized plasma membrane oxidases generate localized reactive oxygen species in response to growth factors and cytokines, driving normal cellular signal transduction through reversible redox modifications.

Cite This Study

Thannickal et al. (2000) studied this question.

synapsesocial.com/papers/69fcf565f9b1bbfa2c26ff3e https://doi.org/10.1152/ajplung.2000.279.6.l1005

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Implication

Narrative review demonstrates dual roles of reactive oxygen species in physiological signaling and macromolecular damage, highlighting targeted redox mechanisms in disease pathogenesis.

Reactive oxygen species in cell signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

Reactive oxygen species in cell signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

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