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Summarize current evidence regarding the generation of reactive oxygen species across subcellular compartments and their roles in mediating metabolic and inflammatory signaling in disease.

March 15, 2018Circulation ResearchOpen Access

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

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Summarize current evidence regarding the generation of reactive oxygen species across subcellular compartments and their roles in mediating metabolic and inflammatory signaling in disease.
Reviewed literature investigating ROS production within the cytoplasm, mitochondria, peroxisomes, and endoplasmic reticulum.
Synthesized findings on downstream interactions between redox signaling, proteasome degradation, autophagy, and inflammatory pathways in metabolic and vascular conditions.
Subcellular ROS production acts as a critical regulator of essential cellular quality-control pathways, including proteasome function and autophagy.
Impairments in redox balance drive pathological inflammatory cascades underlying major metabolic disorders such as atherosclerosis, diabetes mellitus, and stroke.
Targeted therapies require discriminating between specific cellular sources and individual ROS types to restore physiological homeostasis without disrupting beneficial signaling.

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Implication

Narrative review reveals the dual roles of reactive oxygen species in metabolic signaling, highlighting potential therapeutic targets for cardiovascular diseases.

Cite This Study

Forrester et al. (2018) studied this question.

synapsesocial.com/papers/69d8d259ade63f05b9bed9dd https://doi.org/10.1161/circresaha.117.311401

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Implication

Narrative review reveals the dual roles of reactive oxygen species in metabolic signaling, highlighting potential therapeutic targets for cardiovascular diseases.

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

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Implication

Cite This Study

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

Key Points

Discussion

Implication

Cite This Study

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