Why the study?
LVH is an independent predictor of cardiac mortality, but the relationship between LVH and myocardial fibrosis defined by LGE CMR is not well understood.
Does contrast-enhanced CMR detect differences in the incidence and patterns of myocardial fibrosis among patients with different forms of left ventricular hypertrophy?
Population
83 patients with global LVH on CMR from AS, AH, or HCM
Comparison
Patterns and incidence of LGE across AS vs AH vs HCM
Design
Observational cross-sectional CMR study
Authors
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LGE links fibrosis to remodeling severity across LVH etiologies; hypothesis-generating for risk tools but should not yet change practice.**[[1]](https://www.jacc.org/doi/10.1016/j.jacc.2008.08.
Does contrast-enhanced CMR detect differences in the incidence and patterns of myocardial fibrosis among patients with different forms of left ventricular hypertrophy?
Contrast-enhanced CMR reveals that myocardial fibrosis is a frequent feature of left ventricular hypertrophy regardless of its underlying etiology (AS, AH, or HCM) and correlates with the severity of LV remodeling.
Rudolph et al. (2009) studied this question.