Population
Canine ventricular myocytes from control dogs and dogs affected by congestive heart failure induced by…
Comparison
Ventricular pacing to induce heart failure vs Control dogs (unpaced)
Design
Preclinical
Authors
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May implicate myocyte p53-RAS axis in HF progression; leaves open relevance to human disease and therapy.
Canine ventricular myocytes possess a local renin-angiotensin system that is upregulated during pacing-induced heart failure, potentially contributing to disease progression.
Barlucchi et al. (2001) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: