May 1, 2000Cardiovascular Research

Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis

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Population

Cardiac fibroblasts (in vitro models)

Design

Review

Authors

DMDeidre A. MacKennaRegulus Therapeutics (United States)

Discussion

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Implication

Hypothesis-generating for fibroblast mechanotransduction in fibrosis; does not support clinical interventions without in vivo validation.

Structured PICO

Population

Cardiac fibroblasts (in vitro models)

Intervention

Mechanical stimuli (in vitro strain apparatuses)

Outcome

Extracellular matrix (ECM) synthesis and gene expression

Mechanical overload directly modulates cardiac fibroblast function to increase extracellular matrix deposition, providing a mechanistic basis for myocardial fibrosis.

Cite This Study

Deidre A. MacKenna (2000) studied this question.

synapsesocial.com/papers/69fd27bb180198535449026b https://doi.org/10.1016/s0008-6363(00)00030-4

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Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider