July 1, 1991Circulation ResearchOpen Access

Impaired diastolic function and coronary reserve in genetic hypertension. Role of interstitial fibrosis and medial thickening of intramyocardial coronary arteries.

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Why the study?

Does lisinopril improve diastolic stiffness and coronary reserve by reversing structural remodeling in spontaneously hypertensive rats?

Population

14-week-old male spontaneously hypertensive rats with established hypertension and left ventricular…

Comparison

Oral lisinopril for 12 weeks, either low-dose or… vs Age- and sex-matched 26-week-old untreated…

Design

Preclinical

Follow-up

12 weeks

Authors

CBChristian G. BrillaUniversitätsklinikum Tübingen JJJoseph S. JanickiHeart Failure & Transplant KWK. T. WeberIdaho State University

Discussion

Member takes

Implication

Supports interstitial fibrosis as driver of diastolic stiffness independent of LVH; hypothesis-generating for dose-dependent vascular effects in hypertension.

Structured PICO

Does lisinopril improve diastolic stiffness and coronary reserve by reversing structural remodeling in spontaneously hypertensive rats?

Population

14-week-old male spontaneously hypertensive rats with established hypertension and left ventricular hypertrophy (LVH) (n=40 total across 4 groups)

Intervention

Oral lisinopril for 12 weeks, either low-dose (2.5 mg/kg/day) or high-dose (20 mg/kg/day)

Comparator

Age- and sex-matched 26-week-old untreated spontaneously hypertensive rats and normotensive Wistar-Kyoto rats

Outcome

Blood pressure, LVH regression, myocardial interstitial and perivascular fibrosis, diastolic stiffness, medial wall thickening of intramyocardial coronary arteries, and coronary vasodilator reservesurrogate

In a hypertensive rat model, interstitial fibrosis drives abnormal diastolic stiffness independently of LVH, while medial wall thickening of resistance vessels impairs coronary reserve.

Cite This Study

Brilla et al. (1991) studied this question.

synapsesocial.com/papers/69fd27bb1801985354490270 https://doi.org/10.1161/01.res.69.1.107

Topics

Hypertension management

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Implication

Supports interstitial fibrosis as driver of diastolic stiffness independent of LVH; hypothesis-generating for dose-dependent vascular effects in hypertension.

Impaired diastolic function and coronary reserve in genetic hypertension. Role of interstitial fibrosis and medial thickening of intramyocardial coronary arteries.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Impaired diastolic function and coronary reserve in genetic hypertension. Role of interstitial fibrosis and medial thickening of intramyocardial coronary arteries.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider