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May 24, 2011JAMA

Association of Copeptin and N-Terminal proBNP Concentrations With Risk of Cardiovascular Death in Older Patients With Symptoms of Heart Failure

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Why the study?

Are elevated plasma concentrations of copeptin and NT-proBNP associated with increased risk of mortality in elderly patients with symptoms of heart failure?

Population

470 elderly patients with heart failure symptoms from a primary health care population in Sweden

Comparison

Measurement of plasma concentrations of copeptin… vs Lower concentrations of copeptin and NT-proBNP

Design

Cohort

Follow-up

median 13 years

Authors

UAUrban AlehagenLinköping University

Discussion

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Implication

May support risk stratification in symptomatic elderly HF; leaves open prospective validation of incremental value over NT-proBNP.

Structured PICO

Are elevated plasma concentrations of copeptin and NT-proBNP associated with increased risk of mortality in elderly patients with symptoms of heart failure?

P
Population
470 elderly patients with heart failure symptoms from a primary health care population in Sweden
I
Intervention
Measurement of plasma concentrations of copeptin and NT-proBNP
C
Comparator
Lower concentrations (first quartile) of copeptin and NT-proBNP
O
Outcome
All-cause mortality and cardiovascular mortalityhard clinical

Elevated concentrations of copeptin, alone and in combination with NT-proBNP, are associated with an increased risk of long-term all-cause and cardiovascular mortality in elderly patients with heart failure symptoms.

Cite This Study

Urban Alehagen (2011) studied this question.

synapsesocial.com/papers/69fd27cc18019853544902achttps://doi.org/10.1001/jama.2011.666

Topics

Heart failureHFrEF treatment
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Also Consider

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  4. 4Time Course of B-Type Natriuretic Peptide (BNP) and N-Terminal ProBNP Changes in Patients with Decompensated Heart Failure2004 · 41 citations