Clinical and Genetic Heterogeneity of Right Bundle Branch Block and ST-Segment Elevation Syndrome
Why the study?
Are asymptomatic patients with Brugada syndrome at lower risk for sudden death compared to symptomatic patients?
Population
60 patients with typical ECG pattern of right bundle branch block and ST-segment elevation in leads V1 to…
Comparison
Clinical evaluation, programmed electrical… vs Symptomatic vs asymptomatic patients
Design
Cohort
Follow-up
mean 33+/-38 months
Authors
Discussion
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Member takes
Implication
Supports lower VF risk in asymptomatic Brugada patients; hypothesis-generating and should not yet change practice.
Structured PICO
Are asymptomatic patients with Brugada syndrome at lower risk for sudden death compared to symptomatic patients?
P
Population
60 patients (45 males, mean age 40+/-15 years) with typical ECG pattern of right bundle branch block and ST-segment elevation in leads V1 to V3 (Brugada syndrome), including 30 symptomatic (aborted sudden death or syncope) and 30 asymptomatic patients.
I
Intervention
Clinical evaluation, programmed electrical stimulation, and pharmacological challenge with sodium channel blockers
C
Comparator
Symptomatic vs asymptomatic patients
O
Outcome
Ventricular fibrillation during follow-uphard clinical
Asymptomatic patients with Brugada syndrome are at lower risk for sudden death than previously thought, challenging the recommendation for aggressive management with ICDs in this group.
Cite This Study
Priori et al. (2000) studied this question.