Early-stage hypertrophic cardiomyopathy may be better conceptualized and managed as an acquired channelopathy driven by ion channel impairment and myofilament Ca2+ sensitization.
-currents due to transcriptional regulation occurs in the advanced disease and contributes to reducing the repolarization-reserve and increasing the early afterdepolarizations (EADs). The presented evidence supports the idea that patients with early-stage HCM should be considered and managed as subjects with an acquired channelopathy rather than with a structural cardiac disease.
Santini et al. (Mon,) studied this question.