Why the study?
Does candesartan or captopril prevent atrial effective refractory period shortening in dogs undergoing rapid atrial pacing?
Does candesartan or captopril prevent atrial effective refractory period shortening in dogs undergoing rapid atrial pacing?
Inhibition of endogenous Ang II with candesartan or captopril prevents atrial electrical remodeling during rapid atrial pacing in a canine model.
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Does not support clinical use in AF; leaves open whether Ang II inhibition prevents remodeling in patients.
Nakashima et al. (2000) studied this question.
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