Why the study?
Does losartan reduce reperfusion arrhythmias in dogs undergoing coronary occlusion and reperfusion?
Does losartan reduce reperfusion arrhythmias in dogs undergoing coronary occlusion and reperfusion?
In a canine model, blockade of the angiotensin II receptor with losartan has beneficial effects on reperfusion arrhythmias by preventing the decrease in ventricular fibrillation threshold.
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Losartan may attenuate reperfusion VF vulnerability in canine models; leaves open clinical translation of AT1 blockade.
Kumagai et al. (1997) studied this question.
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