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April 3, 2013Journal of Hypertension

Antihypertensive classes, cognitive decline and incidence of dementia

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Why the study?

Does antihypertensive treatment reduce the incidence of dementia and cognitive decline in hypertensive patients without prior cerebrovascular disorders?

Population

Hypertensive patients without prior cerebrovascular disorders. Included 19 randomized trials for cognition…

Comparison

Antihypertensive treatment vs Control group or other antihypertensive classes

Design

Meta-analysis

Authors

NMNatacha Levi MarpillatInsermIMIsabelle Macquin‐MavierUniversité Paris-Est CréteilATAnne‐Isabelle TropeanoAssistance Publique – Hôpitaux de Paris

Discussion

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Implication

Supports antihypertensive treatment, especially ARBs, to lower dementia risk; reinforces and extends mixed trial-observational evidence.

Structured PICO

Does antihypertensive treatment reduce the incidence of dementia and cognitive decline in hypertensive patients without prior cerebrovascular disorders?

P
Population
Hypertensive patients without prior cerebrovascular disorders. Included 19 randomized trials (n=18,515) for cognition and 11 studies (n=831,674) for incidence of dementia.
I
Intervention
Antihypertensive treatment (including angiotensin II receptor blockers, beta-blockers, diuretics, and angiotensin-converting enzyme inhibitors)
C
Comparator
Control group (placebo) or other antihypertensive classes
O
Outcome
Incidence of dementia and cognitive function

Antihypertensive treatment reduces the risk of dementia and cognitive decline in hypertensive patients, with angiotensin II receptor blockers potentially offering the greatest cognitive benefit.

Cite This Study

Marpillat et al. (2013) studied this question.

synapsesocial.com/papers/69fd3af873de1e044f5090a7https://doi.org/10.1097/hjh.0b013e3283603f53

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of the treatment of isolated systolic hypertension on behavioral variables. Results from the systolic hypertension in the elderly program1994 · 251 citations
  2. 2Effects of beta-blockade and exercise on cardiovascular and cognitive functioning.1988 · 15 citations
  3. 3Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's treatment trial of hypertension in older adults1996 · 316 citations
  4. 4Effects of Antihypertensive Medications on Quality of Life in Elderly Hypertensive Women1994 · 48 citations
  5. 5Network meta‐analysis for indirect treatment comparisons2002 · 1,213 citations