Why the study?
Does antihypertensive treatment with indapamide and optional perindopril reduce incident dementia in hypertensive patients aged 80 years or older?
Population
3,336 patients aged 80 years or older with hypertension and no clinical diagnosis of dementia at baseline.
Comparison
1.5 mg slow release indapamide, with the option… vs Matching placebo.
Design
RCT, randomly assigned, double-blind, placebo-controlled
Follow-up
mean 2.2 years
Authors
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Does not support dementia prevention with indapamide-based therapy in octogenarian hypertensives; confirms null effect on incident dementia.
Does antihypertensive treatment with indapamide and optional perindopril reduce incident dementia in hypertensive patients aged 80 years or older?
In very elderly patients with hypertension, blood pressure lowering with indapamide with or without perindopril did not significantly reduce incident dementia over a short follow-up of 2.2 years.
Peters et al. (2008) studied this question.
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