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February 11, 2013CirculationOpen Access

Elevated Blood Pressure in Pregnancy and Subsequent Chronic Disease Risk

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Why the study?

Does elevated blood pressure during pregnancy increase the risk of subsequent cardiovascular and chronic diseases in women?

Population

10,314 women from the Northern Finland Birth Cohort 1966 with blood pressure measurements and prospective…

Comparison

Hypertension during pregnancy vs Normotensive women during pregnancy

Design

Cohort

Follow-up

average 39.4 years

Authors

TMTuija MännistöUniversity of Eastern FinlandPMPauline MendolaUniversity at Buffalo, State University of New YorkMVMarja VääräsmäkiOulu University Hospital

Discussion

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Implication

Gestational hypertension may warrant closer long-term cardiometabolic surveillance; extends observational links but leaves causal effects and interventions open.

Structured PICO

Does elevated blood pressure during pregnancy increase the risk of subsequent cardiovascular and chronic diseases in women?

P
Population
10,314 women from the Northern Finland Birth Cohort 1966 with blood pressure measurements and prospective data from prenatal care records and questionnaires
I
Intervention
Hypertension during pregnancy (including gestational hypertension, isolated systolic hypertension, isolated diastolic hypertension, and chronic hypertension with superimposed preeclampsia/eclampsia)
C
Comparator
Normotensive women during pregnancy
O
Outcome
Subsequent cardiovascular disease, arterial hypertension, ischemic heart disease, myocardial infarcts, myocardial infarct death, heart failure, ischemic stroke, kidney disease, and diabetes mellitus ascertained from Finnish registrieshard clinical

Elevated blood pressure during pregnancy, regardless of type, is a significant risk factor for long-term cardiovascular disease, chronic kidney disease, and diabetes mellitus.

Cite This Study

Männistö et al. (2013) studied this question.

synapsesocial.com/papers/69fd56575c6eda2188019163https://doi.org/10.1161/circulationaha.112.128751

Topics

Women and heart diseaseHeart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prepregnancy cardiovascular risk factors as predictors of pre-eclampsia: population based cohort study2007 · 372 citations
  2. 2Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study2003 · 725 citations
  3. 3Hypertensive Pregnancy Disorders and Subsequent Cardiovascular Morbidity and Type 2 Diabetes Mellitus in the Mother2009 · 654 citations
  4. 4Preeclampsia and the Risk of End-Stage Renal Disease2008 · 651 citations
  5. 5Risk stratification in hypertension: new insights from the Framingham study*12000 · 578 citations