August 1, 1998The Journal of Clinical Endocrinology & Metabolism
Resistance to Insulin-Mediated Glucose Disposal as a Predictor of Cardiovascular Disease
Why the study?
Does resistance to insulin-mediated glucose disposal predict the development of cardiovascular disease in healthy, nonobese volunteers?
Population
147 normal, healthy, nonobese volunteers
Comparison
Resistance to insulin-mediated glucose disposal vs Insulin sensitive subjects
Design
Cohort
Follow-up
mean 4.7 +/- 0.1 years
Authors
Discussion
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Member takes
Implication
Insulin resistance may mark higher CVD risk in healthy nonobese adults; hypothesis-generating and requires prospective confirmation before guiding practice.
Structured PICO
Does resistance to insulin-mediated glucose disposal predict the development of cardiovascular disease in healthy, nonobese volunteers?
P
Population
147 normal, healthy, nonobese volunteers
I
Intervention
Resistance to insulin-mediated glucose disposal (measured by steady state plasma glucose concentration)
C
Comparator
Insulin sensitive subjects (lowest tertile of steady state plasma glucose concentration)
O
Outcome
Development of cardiovascular disease (hypertension, coronary artery disease, cerebrovascular accident, or peripheral vascular disease)composite
Insulin resistance is a significant, independent predictor of future cardiovascular disease events in healthy, nonobese individuals.
Cite This Study
Yip et al. (1998) studied this question.