Why the study?
Does selective extraction of cells and extracellular matrix proteins affect calcification in porcine aorta implanted in rats?
Population
Porcine aorta subdermally implanted in young rats
Comparison
Selective extraction of cells and extracellular… vs Control fresh porcine aorta
Design
Preclinical
Follow-up
21 days
Authors
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Elastin degradation may promote independent calcification in tissue-engineered grafts; leaves open clinical relevance for bioprosthetic durability.
Does selective extraction of cells and extracellular matrix proteins affect calcification in porcine aorta implanted in rats?
Elastin components of the aorta may undergo independent calcification irrespective of devitalized cell-mediated calcification, highlighting the importance of studying elastin-oriented calcification in tissue-engineering applications.
Bailey et al. (2003) studied this question.
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