Why the study?
Does sodium dodecyl sulfate preincubation or sustained administration prevent calcification of glutaraldehyde pretreated porcine aortic valve cusps in a rat subdermal implant model?
Population
Glutaraldehyde pretreated porcine aortic valve cusps (PAV) implanted subdermally in 3-week-old male rats
Comparison
Preincubation of PAV in 1% sodium dodecyl… vs Untreated PAV controls, or nondrug silicone…
Design
Preclinical
Follow-up
21 days
Authors
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SDS preincubation may mitigate bioprosthetic valve calcification; hypothesis-generating and leaves open clinical translation.
Does sodium dodecyl sulfate preincubation or sustained administration prevent calcification of glutaraldehyde pretreated porcine aortic valve cusps in a rat subdermal implant model?
Sodium dodecyl sulfate preincubation, but not sustained release, inhibits calcification of bioprosthetic porcine aortic valves primarily through phospholipid extraction.
Hirsch et al. (1993) studied this question.
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