Key result
After 3 days of in vitro testing, calcium levels were lower in 24-hour UV irradiated porcine aortic leaflets (108.6 +/- 7.6 microg/cm3) compared to glutaraldehyde-pretreated leaflets (257.6 +/- 23.5 microg/cm3).
Why the study?
Does UV irradiation crosslinking reduce calcium deposition in porcine aortic valve leaflets compared to glutaraldehyde pretreatment?
Does UV irradiation crosslinking reduce calcium deposition in porcine aortic valve leaflets compared to glutaraldehyde pretreatment?
Absolute Event Rate: 108.6% vs 257.6%
UV irradiation may be an efficient crosslinking method for bioprosthetic valves that reduces the rapid calcification associated with standard glutaraldehyde pretreatment.
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UV crosslinking may reduce early calcification in porcine leaflets in vitro; leaves open durability benefits for clinical bioprosthetic valves.
Suh et al. (2000) studied Bioprosthetic valve calcification. Ultraviolet (UV) irradiation vs. Glutaraldehyde (GA)-pretreated leaflets and control was evaluated on Calcium levels after 3 days of in vitro calcification test. After 3 days of in vitro testing, calcium levels were lower in 24-hour UV irradiated porcine aortic leaflets (108.6 +/- 7.6 microg/cm3) compared to glutaraldehyde-pretreated leaflets (257.6 +/- 23.5 microg/cm3).
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