Why the study?
Glutaraldehyde-fixed bioprosthetic valves fail due to progressive dystrophic calcification, and treatments to eliminate calcification have not been entirely successful.
Does a combination of calcitonin, sodium bisulfite, Tween 80, and alcohol reduce calcification in glutaraldehyde-fixed porcine aortic leaflets implanted in rats?
Does a combination of calcitonin, sodium bisulfite, Tween 80, and alcohol reduce calcification in glutaraldehyde-fixed porcine aortic leaflets implanted in rats?
The combination of calcitonin, sodium bisulfite, Tween 80, and alcohol significantly mitigates calcification of glutaraldehyde-fixed bioprosthetic tissue in a rat model.
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Should not change valve selection or implantation practices; leaves open translation of combined anticalcification strategies to clinical use.
Agathos et al. (2019) studied this question.
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