Key result
PEG-TA crosslinked valve leaflets demonstrated higher thermal denaturation temperatures and improved mechanical properties compared to glutaraldehyde crosslinked valves (p<0.001).
p-value: p=<0.001
PEG-TA crosslinking of decellularized porcine aortic valve leaflets improves thermal stability, biocompatibility, anticalcification, and mechanical properties compared to standard glutaraldehyde fixation.
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Does not support clinical adoption of PEG-TA valves; leaves open translation of preclinical benefits to human durability.
Hu et al. (2013) studied Bioprosthetic heart valves. Branched poly(ethylene glycol) tetraacrylate (PEG-TA) crosslinked valve leaflets vs. Decellularized valves and glutaraldehyde (GA) crosslinked valves was evaluated on Thermal stability, hydrolyzation rate, cytocompatibility, thrombogenesis, hemolysis, anticalcification, and mechanical properties (p=<0.001). PEG-TA crosslinked valve leaflets demonstrated higher thermal denaturation temperatures and improved mechanical properties compared to glutaraldehyde crosslinked valves (p<0.001).
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