Why the study?
Do diphosphonate compounds inhibit calcification of subcutaneously implanted porcine bioprosthetic heart valve cusps in rats?
Population
3-week-old male rats with subcutaneously implanted glutaraldehyde cross-linked porcine aortic valve cusps
Comparison
Diphosphonate compounds vs Control valves (no diphosphonate treatment)
Design
Preclinical
Follow-up
Up to 21 days (or 35 days for prolonged effect assessment)
Authors
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Does not support clinical use in bioprosthetic valves; leaves open translation from rat models to humans.
Do diphosphonate compounds inhibit calcification of subcutaneously implanted porcine bioprosthetic heart valve cusps in rats?
Diphosphonates inhibit calcification of bioprosthetic heart valves in a rat model, and adverse systemic effects can be avoided by local administration or preincubation.
Levy et al. (1985) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: