Why the study?
Does local controlled-release ethanehydroxydiphosphonate prevent calcification of subcutaneously implanted bioprosthetic heart valves in rats?
Population
Rats with subcutaneously implanted bioprosthetic heart valve cusps (fabricated from porcine aortic valves)
Design
Preclinical
Authors
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Local delivery may avert bioprosthetic valve calcification in rats without growth toxicity; leaves open human translation and durability.
Does local controlled-release ethanehydroxydiphosphonate prevent calcification of subcutaneously implanted bioprosthetic heart valves in rats?
Local controlled-release of ethanehydroxydiphosphonate effectively prevents calcification of bioprosthetic valves in a rat model without causing systemic adverse effects on bone and somatic growth.
Levy et al. (1985) studied this question.
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