Key result
Treatment of fresh porcine aortic cusps with 1% SDS caused severe collagen damage and loss of hydrothermal stability, which was largely prevented by prior glutaraldehyde fixation.
Why the study?
Does 1% sodiumdodecylsulphate (SDS) treatment cause structural damage to fresh and glutaraldehyde-fixed porcine aortic cusps?
Population
Fresh and glutaraldehyde-fixed porcine aortic cusps
Comparison
Treatment with 1% sodiumdodecylsulphate (SDS) vs Before treatment (baseline comparison)
Design
Preclinical
Authors
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Glutaraldehyde fixation before SDS may preserve porcine cusp integrity for bioprostheses; leaves open in vivo durability benefits.
Does 1% sodiumdodecylsulphate (SDS) treatment cause structural damage to fresh and glutaraldehyde-fixed porcine aortic cusps?
Glutaraldehyde fixation prior to 1% SDS treatment protects porcine aortic cusps from the severe structural damage caused by SDS alone, which is relevant for the preparation of bioprostheses.
Bodnár et al. (1986) studied Calcification in porcine aortic or pericardial bioprostheses. Sodiumdodecylsulphate (SDS) vs. Before treatment / Glutaraldehyde fixation prior to SDS was evaluated on Hydrothermal stability, histological and electronmicroscopic appearance. Treatment of fresh porcine aortic cusps with 1% SDS caused severe collagen damage and loss of hydrothermal stability, which was largely prevented by prior glutaraldehyde fixation.
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