What question did this study set out to answer?

To optimize glutaraldehyde-fixed porcine pericardium using aldehyde detoxification and a chondroitin sulfate hydrogel coating to promote endothelialization and protect against structural valve deterioration.

March 14, 2018BiomacromoleculesOpen Access

Optimizing Glutaraldehyde-Fixed Tissue Heart Valves with Chondroitin Sulfate Hydrogel for Endothelialization and Shielding against Deterioration

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Population

Porcine glutaraldehyde-fixed pericardium

Design

Preclinical

Authors

MLMario López-MoyaInstitut Químic de Sarrià PMPedro Melgar‐LesmesCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas KKKumaran KolandaiveluBrigham and Women's Hospital

Discussion

Member takes

Implication

May support longer valve durability in young patients; leaves open clinical translation of enhanced endothelialization.

Key Points

To optimize glutaraldehyde-fixed porcine pericardium using aldehyde detoxification and a chondroitin sulfate hydrogel coating to promote endothelialization and protect against structural valve deterioration.
Subjected glutaraldehyde-fixed porcine pericardium to a chemical detoxification protocol to reduce residual aldehyde toxicity.
Engineered and applied a biodegradable methacrylated chondroitin sulfate hydrogel coating to the pericardial tissue surface.
Assessed endothelial cell proliferation, migration, progenitor cell recruitment, and thromboresistance in the modified tissue.
Glutaraldehyde detoxification combined with chondroitin sulfate hydrogel coating substantially decreased aldehyde cytotoxicity.
The hydrogel-coated pericardium increased endothelial cell migration, proliferation, and endothelial progenitor cell recruitment.
The optimized surface conferred thromboresistance and promoted in situ endothelialization mechanisms to mimic native valve biology.

Structured PICO

Population

Porcine glutaraldehyde-fixed pericardium

Intervention

Glutaraldehyde detoxification combined with a biodegradable methacrylated chondroitin sulfate hydrogel coating

Outcome

Endothelialization, aldehydes cytotoxicity, migration and proliferation of endothelial cells, recruitment of endothelial cell progenitors, and thromboresistancesurrogate

Coating glutaraldehyde-fixed pericardium with chondroitin sulfate hydrogel after detoxification promotes endothelialization and thromboresistance, offering a potential strategy to improve bioprosthetic valve longevity.

Cite This Study

López-Moya et al. (2018) studied this question.

synapsesocial.com/papers/6a70556735aa2c282ce1a33d https://doi.org/10.1021/acs.biomac.8b00077

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Optimizing Glutaraldehyde-Fixed Tissue Heart Valves with Chondroitin Sulfate Hydrogel for Endothelialization and Shielding against Deterioration

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Optimizing Glutaraldehyde-Fixed Tissue Heart Valves with Chondroitin Sulfate Hydrogel for Endothelialization and Shielding against Deterioration

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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