Why the study?
Glutaraldehyde fixation in bioprosthetic valves causes cytotoxicity and calcification that increase leaflet failure, motivating alternatives.
Do nonglutaraldehyde cross-linking reagents (Alg or Alg-CHO) improve biocompatibility and reduce calcification compared to glutaraldehyde in decellularized bovine pericardial tissues?
Population
Acellular bovine pericardial tissues and juvenile Wistar rats
Comparison
Alg or Alg-CHO fixation vs GA control and commercially available Sino product
Design
In vitro and in vivo preclinical animal study
Authors
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Alternative cross-linking may mitigate GA cytotoxicity and calcification in animal models; leaves open clinical translation for bioprosthetic valves.
Do nonglutaraldehyde cross-linking reagents (Alg or Alg-CHO) improve biocompatibility and reduce calcification compared to glutaraldehyde in decellularized bovine pericardial tissues?
Nonglutaraldehyde cross-linking reagents using alginate derivatives show promise as a less toxic, calcification-resistant alternative to glutaraldehyde for bioprosthetic cardiac valves.
Liu et al. (2019) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: