Glucagon-like peptide-1 receptor agonists and gastric emptying time: a systematic review and meta-analysis of prospective studies

Alisia Chen; Karen Zhao; Felicia Ceban; Majid Nabipoor; Marina Englesakis; Frances Chung; Anahi Perlas

doi:10.1007/s12630-026-03114-6

May 5, 2026Canadian Journal of Anesthesia/Journal canadien d anesthésieOpen Access

Glucagon-like peptide-1 receptor agonists and gastric emptying time: a systematic review and meta-analysis of prospective studies

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Key Points

This review aims to evaluate the effect of glucagon-like peptide-1 receptor agonists on gastric emptying time based on prospective studies.
Conducted a systematic review and meta-analysis of prospective cohort studies and randomized controlled trials.
Searched multiple databases including MEDLINE and Cochrane Central Register of Controlled Trials.
Assessed study quality using GRADE and risk of bias tools.
Quantified mean prolongation of gastric emptying by 74 minutes (standardized mean difference 2.38; 95% CI 1.05 to 3.71; P < 0.001).
Observed a trend for short-acting GLP-1 receptor agonists showing a greater effect, prolonging time by 116 minutes (SMD 3.86; 95% CI 2.37 to 5.35).
Early treatment phases (< 10 weeks) indicated a mean prolongation of 82 minutes (SMD 2.72; 95% CI 1.15 to 4.35).

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Implication

Systematic review analyzes the impact of GLP-1 receptor agonists on gastric emptying in various studies, suggesting significant implications for care.

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Chen et al. (2026) studied this question.

synapsesocial.com/papers/69fd7cd4bfa21ec5bbf05a7b https://doi.org/10.1007/s12630-026-03114-6

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Glucagon-like peptide-1 receptor agonists and gastric emptying time: a systematic review and meta-analysis of prospective studies

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Glucagon-like peptide-1 receptor agonists and gastric emptying time: a systematic review and meta-analysis of prospective studies

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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