Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 8, 2026PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

Lysosomes as Regulators of Cancer Stemness and Drug Resistance

View Full Paper
Ask AI
Bookmark
Share

Authors

FZFa-Xiao ZHOUDYDi-Ping YUSTSi‐Qi Tan

Discussion

Loading...

Member takes

Overview

Review explores lysosomal roles in cancer stemness and drug resistance, suggesting therapeutic targeting strategies.

Key Points

  • This review investigates how lysosomes control cancer stem cell properties and contribute to drug resistance.
  • Analysis of lysosomal regulation mechanisms affecting cancer stem cell (CSC) behavior.
  • Assessment of lysophagy, mitophagy, and autophagy-dependent lysosomal degradation pathways.
  • Evaluation of therapeutic strategies targeting lysosomes to combat CSCs.
  • Lysosomes regulate CSC stemness through degradation pathways that either promote or inhibit key stemness proteins.
  • Lysosomal membrane proteins and hydrolases are implicated in maintaining drug resistance in various cancers.
  • Targeting lysosomal function could enhance treatment efficacy against CSCs by overcoming drug resistance mechanisms.

Cite This Study

ZHOU et al. (2026) studied this question.

synapsesocial.com/papers/69fd7d4abfa21ec5bbf05e35https://doi.org/10.3724/j.pibb.2025.0553
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Lysosomal Dysfunction in Hepatocellular Carcinoma: From Pathogenesis to Targeted Therapies2026
  2. 2Targeting lysosome-dependent cell death in cancer: towards therapeutic strategies2026
  3. 3Lipid metabolism dynamics in cancer stem cells: potential targets for cancers2024 · 6 citations
  4. 4Lysosomal Rewiring Perpetuates Tumor Immune Evasion in Cancer2026
  5. 5Cancer stem cells and drug resistance in cancer: molecular mechanisms and therapeutic targets2026