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April 1, 2026PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

The Role of Lysosomal Dysfunction in Hepatocellular Carcinoma: From Pathogenesis to Targeted Therapies

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Authors

YWYueyan WuXCXin ChenCZCefan Zhou

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Overview

This review explores lysosomal dysfunction's role in hepatocellular carcinoma, suggesting new therapeutic strategies to improve treatment outcomes.

Key Points

  • This review aims to elucidate the role of lysosomal dysfunction in hepatocellular carcinoma and its implications for targeted therapies.
  • Synthesis of literature on lysosomal functions in hepatocellular carcinoma
  • Analysis of metabolic reprogramming in tumor cells
  • Evaluation of therapeutic strategies targeting lysosomal pathways
  • Lysosomal dysfunction contributes to therapeutic resistance in HCC
  • HCC cells enhance lysosomal functions to adapt to nutrient-poor environments
  • Targeting lysosomes presents potential strategies for overcoming treatment failure

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69ccb55116edfba7beb875dehttps://doi.org/10.3724/j.pibb.2025.0445
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Searching for novel cellular targets for MASLD and HCC within the humble lysosomal cathepsins2024 · 1 citations
  2. 2Lipid metabolism in cancer cells: Its role in hepatocellular carcinoma progression and therapeutic resistance2025 · 8 citations
  3. 3Dysregulated lipid metabolism in hepatocellular carcinoma: a review of molecular networks and therapeutic opportunities2026
  4. 4Lactylation and targeted therapy resistance in hepatocellular carcinoma.2026 · 1 citations
  5. 5Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)2026