What question did this study set out to answer?

The review aims to summarize the molecular mechanisms of lactylation and its role in hepatocellular carcinoma.

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

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Review shows targeting lactylation may improve understanding and treatment of hepatocellular carcinoma, suggesting new therapeutic strategies.

The review aims to summarize the molecular mechanisms of lactylation and its role in hepatocellular carcinoma.
Systematic review of the molecular basis of lactylation in HCC
Analysis of lactylation's effect on the tumor microenvironment and malignant phenotype
Evaluation of lactylation-related features for clinical applications in HCC
Lactylation is recognized as a significant factor in the metabolic reprogramming of HCC.
Lactylation influences tumor progression and reshapes the tumor microenvironment.
Findings indicate potential use of lactylation features in diagnosis, treatment, and prognosis of HCC.

Chen et al. (2026) studied this question.

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Review shows targeting lactylation may improve understanding and treatment of hepatocellular carcinoma, suggesting new therapeutic strategies.