Protective effects of Lentinula edodes-Undaria pinnatifida sporophyll complex extract on particulate matter-induced damage in A549 cells

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Key Points

This study investigates the protective effects of a Lentinula edodes and Undaria pinnatifida extract on A549 cells damaged by particulate matter.
Assessment of cell viability and LDH activity in A549 cells treated with particulate matter and extract.
Measurement of reactive oxygen species (ROS) generation and inflammatory cytokine expression.
Analysis of apoptosis-related factors, including caspase-3 and Bcl-2.
The extract significantly increased cell viability reduced by PM exposure.
Active inflammatory cytokines TNF-α and IL-6 expression decreased with treatment (p<0.05).
Caspase-3 activity was inhibited, and Bcl-2 expression was restored, suggesting reduced cell death.

Demonstrates protective effects against particulate matter-induced damage in lung cells, suggesting potential therapeutic use.

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김승 (2026) studied this question.

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