February 8, 2016Heart
Global longitudinal strain is associated with heart failure outcomes in hypertrophic cardiomyopathy
Why the study?
Does global longitudinal strain predict cardiac and heart failure outcomes in patients with hypertrophic cardiomyopathy?
Population
472 patients with hypertrophic cardiomyopathy, mean age 50.0±15.0 years, 68% men, at a single tertiary…
Design
Cohort
Follow-up
median 4.3 years
Authors
Discussion
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Implication
GLS may refine HCM risk stratification beyond conventional markers; extends observational data but leaves prospective validation open.
Structured PICO
Does global longitudinal strain predict cardiac and heart failure outcomes in patients with hypertrophic cardiomyopathy?
P
Population
472 patients with hypertrophic cardiomyopathy (HCM), mean age 50.0±15.0 years, 68% men, at a single tertiary institution. Exclusions: left ventricular hypertrophy of other origin, atrial fibrillation, lost to follow-up, and insufficient image quality.
I
Intervention
Global longitudinal strain (GLS) measurement by echocardiography
O
Outcome
Composite of all cardiac deaths, appropriate defibrillator shocks, and heart failure (HF) admissionscomposite
Reduced global longitudinal strain is an independent predictor of poor cardiac outcomes, particularly heart failure events, in patients with hypertrophic cardiomyopathy.
Cite This Study
Réant et al. (2016) studied this question.