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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026ot17 Prehospital Biomarker and Phone Call-Based Detection for Ischaemic Stroke Thrombectomy (Pronto): Work in Progress

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Authors

LSLisa ShawRBRachel BinksGBGreta Brunskill

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Overview

Prospective observational cohort study evaluates biomarker tests and phone alerts for LVO stroke in adults, suggesting improved triage efficiency.

Key Points

  • The research aims to assess if lateral flow biomarker tests can accurately detect large vessel occlusion strokes eligible for thrombectomy in pre-hospital settings.
  • Prospective observational cohort study involving adults with FAST symptoms presenting to ambulance services within 6 hours of onset.
  • Two portable lateral flow assays for detecting D-dimer and Glial Fibrillary Acidic Protein using fingerprick capillary blood.
  • Ambulance practitioners relay test results and clinical information via pre-alert calls to stroke teams.
  • The study includes 496 participants with evaluations of sensitivity, specificity, and predictive values for identifying LVO stroke.
  • Reference standards for LVO diagnosis include CT brain imaging with expert clinician opinion.
  • Suitability for direct comprehensive center admission is based on specific clinical criteria including NIHSS and mRS assessments.

Cite This Study

Shaw et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e23bfa21ec5bbf065efhttps://doi.org/10.1093/esj/aakag023.2020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of the prehospital diagnostic accuracy of a novel point-of-care test for NT-proBNP, D-dimer and H-FABP and large-vessel occlusion risk assessment (LVOCheck-EVA): a protocol for a multicenter prospective observational study in patients suspected of having a stroke2025
  2. 2ABSTRACT NUMBER: ESOC2026A207 PRE-HOSPITAL TRIAGE SYSTEMS FOR LARGE VESSEL OCCLUSION STROKE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF DIAGNOSTIC ACCURACY AND CLINICAL IMPACT2026
  3. 3ABSTRACT NUMBER: ESOC2026LB136 LB136 - PERSONALIZED PREHOSPITAL TRIAGE FOR SUSPECTED ACUTE STROKE (PRESTO-2): IMPLEMENTATION AND EVALUATION OF A REAL-TIME DECISION SUPPORT TOOL2026
  4. 4Diagnostic Accuracy of Lateral Flow Blood Tests to Detect Large Vessel Occlusion Stroke2026
  5. 5ABSTRACT NUMBER: ESOC2026OT133 POC4TRIAGE: POINT-OF-CARE DEVICES FOR URGENT CARE TRIAGE – SUBHAIRLINE ELECTROENCEPHALOGRAPHY AND FUNCTIONAL NEAR-INFRARED SPECTROSCOPY FOR STROKE DETECTION2026