What is the clinical evidence from this study?

Study design: Observational. Population: Suspected acute stroke (n=800). Intervention: LVOCheck point-of-care test vs. Final hospital diagnosis. Primary outcome: Diagnostic accuracy (sensitivity and specificity) for predicting large-vessel occlusion.

What does this research mean for the field?

A novel point-of-care test integrating vascular biomarkers (NT-proBNP, D-Dimer, H-FABP) and clinical decision support software offers a potentially cost-effective approach to support prehospital identification and triage of large-vessel occlusion stroke. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 8, 2025Frontiers in NeurologyOpen Access

Evaluation of the prehospital diagnostic accuracy of a novel point-of-care test for NT-proBNP, D-dimer and H-FABP and large-vessel occlusion risk assessment (LVOCheck-EVA): a protocol for a multicenter prospective observational study in patients suspected of having a stroke

View Full Paper

Ask AI

Bookmark

Key result

This study protocol outlines a planned observational trial to evaluate the diagnostic accuracy of the LVOCheck point-of-care biomarker test for prehospital prediction of large-vessel occlusion in suspected stroke patients.

Why the study?

Prehospital identification of large-vessel occlusion stroke could streamline transport directly to thrombectomy-capable centers, and blood biomarkers measured via point-of-care testing offer a potentially cost-effective alternative to mobile stroke units.

Does the LVOCheck point-of-care test accurately predict large-vessel occlusion in patients with suspected stroke in a prehospital setting?

Population

800 patients with suspected stroke enrolled within 24 h after symptom onset

Comparison

LVOCheck point-of-care test predictive performance vs final diagnoses

Design

Multicenter prospective observational study

Authors

KRKian RöhrsHumboldt-Universität zu Berlin MKMaximilian KaffesHumboldt-Universität zu Berlin FBFulvio BondiHumboldt-Universität zu Berlin

Discussion

Member takes

Implication

This study protocol describes a prospective observational trial to evaluate the diagnostic accuracy of a novel prehospital point-of-care biomarker test for identifying large-vessel occlusion in suspected stroke patients.

Study Design

Type

Observational (n=800)

Multicenter

Yes

Structured PICO

Does the LVOCheck point-of-care test accurately predict large-vessel occlusion in patients with suspected stroke in a prehospital setting?

Population

A planned multicenter prospective observational study of 800 adult patients with suspected acute stroke within 24 hours of symptom onset to evaluate a prehospital point-of-care biomarker test.

Exposure

LVOCheck device, a multiplex point-of-care test measuring NT-proBNP, D-Dimer, and H-FABP from whole-blood, integrated with patient-specific clinical data via a Mobile App to predict large-vessel occlusion (LVO) risk.

Comparator

Standard clinical information alone / gold-standard final hospital diagnosis.

Outcome

Diagnostic accuracy (sensitivity and specificity) of LVOCheck to predict LVO probability, evaluated against the gold-standard final hospital diagnosis.surrogate

Limitations

The biomarker panel has limited ability to differentiate ischemia from intracerebral hemorrhage

Cite This Study

Röhrs et al. (2025) conducted an observational in Suspected acute stroke (n=800). LVOCheck point-of-care test vs. Final hospital diagnosis was evaluated on Diagnostic accuracy (sensitivity and specificity) for predicting large-vessel occlusion. This study protocol outlines a planned observational trial to evaluate the diagnostic accuracy of the LVOCheck point-of-care biomarker test for prehospital prediction of large-vessel occlusion in suspected stroke patients.

synapsesocial.com/papers/6a65797e66784dc805f71b80 https://doi.org/10.3389/fneur.2025.1697711

View Full Paper

Ask AI

Bookmark

December 8, 2025Frontiers in NeurologyOpen Access

Evaluation of the prehospital diagnostic accuracy of a novel point-of-care test for NT-proBNP, D-dimer and H-FABP and large-vessel occlusion risk assessment (LVOCheck-EVA): a protocol for a multicenter prospective observational study in patients suspected of having a stroke

View Full Paper

Ask AI

Bookmark

Key result

Why the study?

Does the LVOCheck point-of-care test accurately predict large-vessel occlusion in patients with suspected stroke in a prehospital setting?

Population

800 patients with suspected stroke enrolled within 24 h after symptom onset

Comparison

LVOCheck point-of-care test predictive performance vs final diagnoses

Design

Multicenter prospective observational study

Authors

KRKian RöhrsHumboldt-Universität zu Berlin MKMaximilian KaffesHumboldt-Universität zu Berlin FBFulvio BondiHumboldt-Universität zu Berlin

Discussion

Member takes

Implication

Study Design

Type

Observational (n=800)

Multicenter

Yes

Structured PICO

Does the LVOCheck point-of-care test accurately predict large-vessel occlusion in patients with suspected stroke in a prehospital setting?

Population

A planned multicenter prospective observational study of 800 adult patients with suspected acute stroke within 24 hours of symptom onset to evaluate a prehospital point-of-care biomarker test.

Exposure

Comparator

Standard clinical information alone / gold-standard final hospital diagnosis.

Outcome

Diagnostic accuracy (sensitivity and specificity) of LVOCheck to predict LVO probability, evaluated against the gold-standard final hospital diagnosis.surrogate

Limitations

The biomarker panel has limited ability to differentiate ischemia from intracerebral hemorrhage

Cite This Study

synapsesocial.com/papers/6a65797e66784dc805f71b80 https://doi.org/10.3389/fneur.2025.1697711

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark