Population
Single smooth muscle cells from myogenic cerebral arteries and pressurized myogenic arteries
Comparison
Ryanodine and thapsigargin vs Blockers of KCa channels / uninhibited state
Design
Preclinical
Authors
Loading...
Hypothesis-generating for spark-KCa vasodilation in animal arteries; leaves open human translation and therapeutic targeting.
Spontaneous local increases in intracellular calcium (Ca2+ sparks) from the sarcoplasmic reticulum indirectly cause arterial vasodilation by activating Ca2+-dependent potassium channels.
Nelson et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: