June 1, 1989Journal of Cerebral Blood Flow & MetabolismOpen Access

Endothelium-Dependent Dilation of Feline Cerebral Arteries: Role of Membrane Potential and Cyclic Nucleotides

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Population

Middle cerebral arteries isolated from cats

Comparison

Acetylcholine (ACh) and ADP vs Preparations without endothelium; presence vs…

Design

Preclinical

Authors

JBJoseph E. BraydenUniversity of Vermont GWGeorge C. WellmanUniversity of Vermont

Discussion

Member takes

Implication

Indicates hyperpolarization-independent endothelium-dependent dilation in feline cerebral arteries; leaves open relevance to human cerebrovascular regulation.

Structured PICO

Population

Middle cerebral arteries isolated from cats

Intervention

Acetylcholine (ACh) and ADP

Comparator

Preparations without endothelium; presence vs absence of inhibitors (ouabain, methylene blue)

Outcome

Vasodilation and membrane hyperpolarizationsurrogate

Endothelium-dependent vasodilation in feline cerebral arteries involves membrane hyperpolarization and at least one other pathway independent of cGMP.

Cite This Study

Brayden et al. (1989) studied this question.

synapsesocial.com/papers/6a7a3c6402ab7a73dd02cc9f https://doi.org/10.1038/jcbfm.1989.42

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Implication

Indicates hyperpolarization-independent endothelium-dependent dilation in feline cerebral arteries; leaves open relevance to human cerebrovascular regulation.