June 1, 1995Circulation Research

Dilatation of Cerebral Arterioles in Response to Activation of Adenylate Cyclase Is Dependent on Activation of Ca2+-Dependent K+Channels

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Population

Anesthetized rabbits (in vivo model)

Comparison

Topical application of forskolin and dibutyryl… vs Control diameter; responses to sodium…

Design

Preclinical

Authors

HTHisao TaguchiNihon University DHDonald D. HeistadOregon National Primate Research Center TKTakanari KitazonoVascular Medicine

Discussion

Member takes

Implication

Forskolin dilates cerebral arterioles via BKCa channels in vivo; leaves open translation to human cerebrovascular disorders.

Structured PICO

Population

Anesthetized rabbits (in vivo model)

Intervention

Topical application of forskolin (1 and 10 mumol/L) and dibutyryl cAMP, with selective inhibitors of Ca(2+)-dependent potassium channels (iberiotoxin 50 and 100 nmol/L, or charybdotoxin 50 nmol/L)

Comparator

Control diameter; responses to sodium nitroprusside, acetylcholine, and aprikalim

Outcome

Diameters of cerebral arterioles (vasodilatation)surrogate

Activation of Ca2+-dependent potassium channels is a major mechanism of cerebral vasodilatation in response to adenylate cyclase activation in vivo.

Cite This Study

Taguchi et al. (1995) studied this question.

synapsesocial.com/papers/6a703dcfe5469ee92be0fe08 https://doi.org/10.1161/01.res.76.6.1057

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Dilatation of Cerebral Arterioles in Response to Activation of Adenylate Cyclase Is Dependent on Activation of Ca2+-Dependent K+Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dilatation of Cerebral Arterioles in Response to Activation of Adenylate Cyclase Is Dependent on Activation of Ca2+-Dependent K+Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider