March 1, 2003Journal of Cardiovascular Pharmacology

cGMP-dependent and Not cAMP-dependent Kinase Is Required for Adenosine-induced Dilation of Intracerebral Arterioles

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Population

Resistance-sized rat cerebral arterioles that develop spontaneous tone

Design

Preclinical

Authors

GWG. Alexander WestHouston Methodist JMJoseph R. MenoUniversity of Washington TNThien-Son NguyenVirginia Mason Medical Center

Discussion

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Implication

Does not support cAMP-targeted therapies in cerebral vessels; hypothesis-generating for cGMP-PKG modulation in human cerebrovascular studies.

Structured PICO

Population

Resistance-sized rat cerebral arterioles that develop spontaneous tone

Intervention

Adenosine (ADO) and cyclic nucleotide pathway modulators (including Rp-8-pCPT-cGMPS, H8, ODQ, and Rp-8-CPT-cAMPS)

Outcome

Arteriolar dilationsurrogate

Adenosine-induced vasodilation in cerebral microvessels is mediated at least in part by cGMP and cGMP-dependent protein kinase, rather than cAMP-dependent pathways.

Cite This Study

West et al. (2003) studied this question.

synapsesocial.com/papers/6a7216f0abc331a85807b54d https://doi.org/10.1097/00005344-200303000-00013

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Implication

Does not support cAMP-targeted therapies in cerebral vessels; hypothesis-generating for cGMP-PKG modulation in human cerebrovascular studies.

cGMP-dependent and Not cAMP-dependent Kinase Is Required for Adenosine-induced Dilation of Intracerebral Arterioles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

cGMP-dependent and Not cAMP-dependent Kinase Is Required for Adenosine-induced Dilation of Intracerebral Arterioles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider