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August 1, 1991AJP Heart and Circulatory Physiology

Adenosine receptor-mediated coronary artery relaxation and cyclic nucleotide production

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Key result

Adenosine analogs trigger coronary artery relaxation through complex signaling beyond direct adenylate cyclase stimulation.

Population

Rings from left anterior descending coronary artery and endothelium-free membrane preparation

Comparison

Adenosine and its analogs (2-chloroadenosine… vs Baseline or addition of ADO receptor antagonist…

Design

Preclinical

Authors

DCD J CushingEli Lilly (United States)GBGeorge L. BrownFitzsimons Army Medical CenterMSM H SabouniEast Carolina University

Discussion

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Implication

Does not yet guide clinical coronary vasomotor therapy; leaves open complex cAMP-independent adenosine pathways for targeted investigation.

Structured PICO

P
Population
Rings from left anterior descending coronary artery (endothelium mechanically removed) and endothelium-free membrane preparation
I
Intervention
Adenosine (ADO) and its analogs (2-chloroadenosine [CAD], l-N6-(2-phenylisopropyl)adenosine [R-PIA], 5'-(N-ethylcarboxamido)adenosine [NECA], and CGS-21680)
C
Comparator
Baseline or addition of ADO receptor antagonist 8-(sulfophenyl)theophylline (8-SPT)
O
Outcome
Coronary artery relaxation and adenylate/guanylate cyclase activitysurrogate

Adenosine receptor-mediated coronary artery relaxation involves cAMP, but the inability of certain analogs to stimulate adenylate cyclase suggests complex signaling mechanisms beyond a single A2 receptor.

Cite This Study

Cushing et al. (1991) studied this question. Adenosine and analogs (ADO, CAD, R-PIA, NECA) was evaluated on Coronary artery relaxation and adenylate cyclase activity. Adenosine receptor-mediated coronary artery relaxation may involve cAMP, but the inability of NECA and CGS-21680 to stimulate adenylate cyclase suggests a more complex signaling mechanism.

synapsesocial.com/papers/6aa5928f3f91f0dc5278f3e9https://doi.org/10.1152/ajpheart.1991.261.2.h343
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery1995 · 71 citations
  2. 2Adenosine receptor-mediated relaxation of porcine coronary artery in presence and absence of endothelium1994 · 96 citations
  3. 3Effects of adenosine receptor agonists on guinea-pig isolated working hearts and the role of endothelium and NO2002 · 21 citations
  4. 4cGMP-dependent and Not cAMP-dependent Kinase Is Required for Adenosine-induced Dilation of Intracerebral Arterioles2003 · 20 citations
  5. 5Release of adenosine and cyclic AMP from coronary endothelium in isolated guinea pig hearts: relation to coronary flow.1987 · 48 citations