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November 1, 1995AJP Heart and Circulatory Physiology

Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery

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Why the study?

Does the nitric oxide pathway mediate the endothelium-dependent vasorelaxant effects of adenosine agonists in porcine coronary arteries?

Population

Porcine coronary artery rings in vitro

Comparison

5'-uronamide adenosine agonists and C2- and… vs Endothelium-denuded rings or absence of inhibitors

Design

Preclinical

Authors

WAWorku AbebeAddis Ababa Science and Technology UniversityTHTahir HussainUniversity of HoustonHOH.A. OlanrewajuU.S. National Poultry Research Center

Discussion

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Overview

Supports NO mediation for NECA/CGS-21680 in porcine coronaries; leaves open translation to human vessels or therapy.

Structured PICO

Does the nitric oxide pathway mediate the endothelium-dependent vasorelaxant effects of adenosine agonists in porcine coronary arteries?

P
Population
Porcine coronary artery rings in vitro
I
Intervention
5'-uronamide adenosine agonists (NECA and CGS-21680) and C2- and N6-substituted analogues (CAD and CPA), with or without NO synthase inhibitor (L-NMMA, 30 microM) or NO-destroying agent (LY-83583, 10 microM)
C
Comparator
Endothelium-denuded rings or absence of inhibitors
O
Outcome
Vasorelaxant effectssurrogate

The nitric oxide pathway mediates the endothelium-dependent vasorelaxant effects of specific adenosine agonists (NECA and CGS-21680) in porcine coronary arteries.

Cite This Study

Abebe et al. (1995) studied this question.

synapsesocial.com/papers/6a8544869df997f4bbd6a469https://doi.org/10.1152/ajpheart.1995.269.5.h1672
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adenosine receptor-mediated relaxation of porcine coronary artery in presence and absence of endothelium1994 · 96 citations
  2. 2Effects of adenosine receptor agonists on guinea-pig isolated working hearts and the role of endothelium and NO2002 · 19 citations
  3. 3EXAMINATION OF ADENOSINE RECEPTOR‐MEDIATED RELAXATION OF THE PIG CORONARY ARTERY1999 · 17 citations
  4. 4Adenosine receptor-mediated coronary artery relaxation and cyclic nucleotide production1991 · 53 citations
  5. 5Nitric Oxide Inhibits α2-Adrenoceptor–Mediated Endothelium-Dependent Vasodilation1998 · 72 citations