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June 29, 1998Circulation ResearchOpen Access

Nitric Oxide Inhibits α2-Adrenoceptor–Mediated Endothelium-Dependent Vasodilation

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Population

Isolated resistance mesenteric arterial segments from mice lacking the gene for constitutive endothelial NO…

Comparison

Oxymetazoline with or without various… vs Wild-type controls and untreated conditions

Design

Preclinical

Authors

ÉTÉric ThorinPHPaul L. HuangMFMark C. Fishman

Discussion

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Overview

NO functionally inhibits alpha2-adrenoceptor relaxation in murine endothelium; leaves open relevance to human vascular tone or therapy.

Structured PICO

P
Population
Isolated resistance mesenteric arterial segments from mice lacking the gene for constitutive endothelial NO synthase (eNOS- mice, n=14) and wild-type controls (WT mice, n=46).
I
Intervention
Oxymetazoline (0.01 to 30 micromol/L) with or without various inhibitors/donors (l-NNA, sodium nitroprusside, methylene blue, tetraethylammonium, glibenclamide)
C
Comparator
Wild-type controls and untreated conditions
O
Outcome
Endothelium-dependent vasorelaxation of isolated mesenteric arteriessurrogate

Nitric oxide functionally inhibits alpha2-adrenoceptor-mediated endothelium-dependent vasodilation, likely by reducing the release or production of an endothelium-derived hyperpolarizing factor via cGMP formation.

Cite This Study

Thorin et al. (1998) studied this question.

synapsesocial.com/papers/6a843d2f74ee596ff2c521d9https://doi.org/10.1161/01.res.82.12.1323
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Also Consider

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  1. 1ACh dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms1996 · 111 citations
  2. 2Modulation by the endothelium of sympathetic vasoconstriction in anin vitropreparation of the rat tail artery1994 · 47 citations
  3. 3Vascular relaxation and cGMP in hypertension1988 · 64 citations
  4. 4Selective Guanylyl Cyclase Inhibitor Reverses Nitric Oxide-Induced Vasorelaxation1997 · 75 citations
  5. 5Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state1995 · 189 citations