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March 22, 2013Journal of Cardiovascular PharmacologyOpen Access

Participation of Nitric Oxide Pathway in the Relaxation Response Induced by E-cinnamaldehyde Oxime in Superior Mesenteric Artery Isolated From Rats

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Population

Endothelium-denuded and intact superior mesenteric rings isolated from rats, precontracted with phenylephrine

Design

Preclinical

Authors

RVRobson Cavalcante VerasKRKaroline G. RodriguesMAMaria do Carmo de Alustau

Discussion

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Overview

E-CAOx shows NO-donor vasorelaxant effects in rat arteries; leaves open any therapeutic translation to human vascular disease.

Structured PICO

P
Population
Endothelium-denuded and intact superior mesenteric rings isolated from rats, precontracted with phenylephrine
I
Intervention
E-cinnamaldehyde oxime (E-CAOx)
O
Outcome
Vasorelaxationsurrogate

E-cinnamaldehyde oxime acts as a nitric oxide donor, inducing vasorelaxation in rat mesenteric arteries via the NO/sGC/PKG pathway and potassium channels.

Cite This Study

Veras et al. (2013) studied this question.

synapsesocial.com/papers/6a709a8b35aa2c282ce1ec14https://doi.org/10.1097/fjc.0b013e31829013ff
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric Oxide Inhibits α<sub>2</sub>-Adrenoceptor–Mediated Endothelium-Dependent Vasodilation1998 · 72 citations
  2. 2Novel Nitric Oxide Synthase–Dependent Mechanism of Vasorelaxation in Small Arteries From Hypertensive Rats2007 · 56 citations
  3. 3Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery1995 · 72 citations
  4. 4NO contributes to EDHF-like responses in rat small arteries: a role for NO stores2002 · 61 citations
  5. 5NO − Activates Soluble Guanylate Cyclase and K v Channels to Vasodilate Resistance Arteries2003 · 146 citations