Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 13, 2003HypertensionOpen Access

NO − Activates Soluble Guanylate Cyclase and K v Channels to Vasodilate Resistance Arteries

View Full Paper
Ask AI
Bookmark
Share

Key result

NO- (Angeli's salt) functions as a potent vasodilator of resistance arteries (Rmax 95.5%), mediating its response independently of NO* via soluble guanylate cyclase and voltage-dependent K+ channels.

Population

Rat small isolated mesenteric resistance-like arteries

Comparison

NO- (Angeli's salt) vs NO* and sodium nitroprusside, evaluated in the…

Design

Preclinical

Authors

JIJennifer C. IrvineAptiv (United States)JFJoanne L FavaloroRMIT VietnamBKBarbara K. Kemp‐HarperDiscovery Institute

Discussion

Loading...

Member takes

Implication

No immediate clinical role for NO- donors; leaves open their development as novel nitrovasodilators in hypertension models.

Structured PICO

P
Population
Rat small isolated mesenteric resistance-like arteries
I
Intervention
NO- (Angeli's salt)
C
Comparator
NO* (NO gas solution) and sodium nitroprusside, evaluated in the presence of various scavengers and inhibitors (carboxy-PTIO, l-Cysteine, ODQ, 4-aminopyridine)
O
Outcome
Vasorelaxation response (measured via standard myographic techniques)surrogate

NO- is a potent vasodilator of resistance arteries that acts independently of NO* via soluble guanylate cyclase and voltage-dependent K+ channels, suggesting NO- donors as a potential novel class of nitrovasodilators.

Cite This Study

Irvine et al. (2003) studied Vascular tone in resistance arteries. NO- (Angeli's salt) vs. NO* (NO gas solution) and sodium nitroprusside was evaluated on Vasorelaxation response (Rmax). NO- (Angeli's salt) functions as a potent vasodilator of resistance arteries (Rmax 95.5%), mediating its response independently of NO* via soluble guanylate cyclase and voltage-dependent K+ channels.

synapsesocial.com/papers/6a9711292af794539aa6cfd0https://doi.org/10.1161/01.hyp.0000072010.54901.de
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence that mechanisms dependent and independent of nitric oxide mediate endothelium‐dependent relaxation to bradykinin in human small resistance‐like coronary arteries1997 · 84 citations
  2. 2Expression of voltage-dependent K+channel genes in mesenteric artery smooth muscle cells1999 · 120 citations
  3. 3Vascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide andnitroxyl ion2001 · 127 citations
  4. 4Differential actions of L‐cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aorta2000 · 95 citations
  5. 5Nitric oxide and sodium nitroprusside‐induced relaxation of the human umbilical artery2000 · 71 citations