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May 8, 2026JMIR AIOpen Access

Evaluating the Potential Impact of AI on Urinary Tract Infection Diagnosis in the Emergency Department Across Demographic Groups: Retrospective Cohort Study

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Authors

MIMark IscoeYale UniversityHLHuan LiCentral South UniversityHXHaipeng XueYale University

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Implication

Retrospective cohort study evaluates AI's diagnostic accuracy for UTI across demographics, indicating potential improvements.

Key Points

  • The aim was to evaluate an AI model's performance in predicting UTI diagnosis across different demographic groups in the emergency department.
  • Multisite retrospective analysis of nonpregnant adults in ED with urinalysis and urine culture from 9 US health system EDs.
  • Developed an extreme gradient boosting model using data from June 2013 to August 2021, employing 5-fold cross-validation.
  • Compared AI model performance in diagnosis with that of physicians, using a composite proxy for physician diagnosis from UTI prescriptions.
  • Out of 149,449 encounters, 22,521 (15.1%) had positive cultures; 20,080 (13.4%) were diagnosed with UTI.
  • AI model achieved an area under the receiver operating characteristic curve of 0.93 (95% CI 0.93-0.93).
  • The AI model had lower overdiagnosis and underdiagnosis rates compared to physicians across all demographic groups.

Cite This Study

Iscoe et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e42bfa21ec5bbf06805https://doi.org/10.2196/91148
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A comparative study of pretrained language models for long clinical text2022 · 148 citations
  2. 2Urinary Tract Infections in Long-Term–Care Facilities2001 · 345 citations
  3. 3Sources of bias in artificial intelligence that perpetuate healthcare disparities—A global review2022 · 567 citations
  4. 4Diagnostic uncertainty and urinary tract infection in the emergency department: a cohort study from a UK hospital2020 · 32 citations