What question did this study set out to answer?

To investigate the cardiac uptake mechanisms of the novel sympathetic nerve imaging tracer 18F-LMI1195 in rats.

September 25, 2006Neurology

Early MRI and outcomes of untreated patients with mild or improving ischemic stroke

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Authors

VRVenkatakrishna RajajeeUniversity of Michigan CKChelsea S. KidwellInstitute for Quantum Optics and Quantum Information Innsbruck SSSidney StarkmanUniversity of California, Los Angeles

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Implication

Preclinical imaging study demonstrates uptake-2-dependent cardiac accumulation of 18F-LMI1195 in rats, indicating distinct species-specific sympathetic transport mechanisms.

Key Points

To investigate the cardiac uptake mechanisms of the novel sympathetic nerve imaging tracer 18F-LMI1195 in rats.
Assessed dynamic tracer accumulation in the heart following intravenous 18F-LMI1195 injection in healthy male Wistar rats using quantitative in vivo PET imaging.
Administered intravenous pretreatments with the nonselective uptake-1/uptake-2 inhibitor phenoxybenzamine (50 mg/kg; n = 4), the selective uptake-1 inhibitor desipramine (2 mg/kg; n = 4), or saline control (n = 4).
18F-LMI1195 demonstrated high and sustained cardiac accumulation, enabling clear delineation of the left ventricular wall throughout 60 minutes of imaging.
Pretreatment with phenoxybenzamine markedly reduced cardiac tracer uptake compared to controls, whereas desipramine pretreatment preserved uptake.

Cite This Study

Rajajee et al. (2006) studied this question.

synapsesocial.com/papers/69fd7e4aeaf018ad124ba0bf https://doi.org/10.1212/01.wnl.0000237520.88777.71

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Implication

Preclinical imaging study demonstrates uptake-2-dependent cardiac accumulation of 18F-LMI1195 in rats, indicating distinct species-specific sympathetic transport mechanisms.

Early MRI and outcomes of untreated patients with mild or improving ischemic stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Early MRI and outcomes of untreated patients with mild or improving ischemic stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

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