Why the study?
Does combined pentoxifylline and alpha-tocopherol improve regression of superficial radiation-induced fibrosis in women previously irradiated for breast cancer?
Population
24 women with 29 radiation-induced fibrosis areas involving the skin and underlying tissues, previously…
Comparison
Pentoxifylline 800 mg/d and alpha-tocopherol… vs PTX plus placebo, placebo plus Vit E, or double…
Design
RCT, randomly assigned to four balanced treatment groups, double-blind…
Follow-up
6 months
Authors
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Supports combined PTX/Vit E for superficial RIF regression; confirms benefit in this RCT of breast cancer survivors.
Does combined pentoxifylline and alpha-tocopherol improve regression of superficial radiation-induced fibrosis in women previously irradiated for breast cancer?
Combined treatment with pentoxifylline and alpha-tocopherol for 6 months significantly reduces superficial radiation-induced fibrosis compared to placebo.
Delanian et al. (2003) studied this question.
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