Key result
Higher admission QTc linked to ~40% greater MACCE risk per SD after ischemic stroke or TIA.
Why the study?
To evaluate the association between admission Bazett-corrected QT-interval on 12-lead ECGs and clinical outcomes after acute ischemic stroke or transient ischemic attack.
Does admission QTc-interval on standard 12-lead ECG predict MACCE, mortality, and recurrent stroke in patients with ischemic stroke or TIA?
RCT (n=1,369)
Does admission QTc-interval on standard 12-lead ECG predict MACCE, mortality, and recurrent stroke in patients with ischemic stroke or TIA?
Effect estimate: HR 1.40 (95% CI 1.14-1.72)
p-value: p=0.001
Higher admission QTc on a standard 12-lead ECG is significantly associated with an increased risk of MACCE, mortality, and recurrent stroke over 24 months in patients with ischemic stroke or TIA.
No takes yet. Share an insight, caveat, or question.
Warrants attention in post-stroke risk assessment; leaves open whether QTc prolongation is a modifiable therapeutic target.
Olma et al. (2026) conducted an RCT in acute ischemic stroke or transient ischemic attack (TIA) (n=1,369). Admission Bazett-corrected QT-interval (QTc) was evaluated on MACCE (recurrent stroke, myocardial infarction, major bleeding, or death) (HR 1.40, 95% CI 1.14-1.72, p=0.001). Per 1 standard deviation increase, admission QTc was associated with an increased risk of MACCE (HR 1.40; 95% CI 1.14-1.72; p=0.001) over 24 months after ischemic stroke or TIA.
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