What question did this study set out to answer?

The aim was to compare neurological and functional outcomes between tenecteplase and alteplase in acute ischemic stroke patients.

May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a2442 Tenecteplase Versus Alteplase in Acute Ischemic Stroke: A Real-World Comparative Study

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Authors

RFRui FernandesAdministração Regional de Saúde de Lisboa e Vale do Tejo TMTeresa MoraisEscola Superior de Tecnologia da Saúde de Coimbra DDDaniela DinizFederal University of São João del-Rei

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Implication

Retrospective study compares neurological and functional outcomes in patients with ischemic stroke treated with tenecteplase or alteplase, suggesting both are viable options.

Key Points

The aim was to compare neurological and functional outcomes between tenecteplase and alteplase in acute ischemic stroke patients.
Retrospective observational study of AIS patients treated with intravenous thrombolysis in 2025.
Patients received either tenecteplase (n=16) or alteplase (n=69).
Analyses included NIHSS, mRS, door-to-needle time, and hemorrhagic transformation.
Median NIHSS at discharge was 2 for tenecteplase and 3 for alteplase (p=0.505).
Median mRS scores at discharge were 1 for tenecteplase and 3 for alteplase (p=0.358).
Neurological improvement and hemorrhagic transformation rates were similar between treatments.

Cite This Study

Fernandes et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e79bfa21ec5bbf06c06 https://doi.org/10.1093/esj/aakag023.1838

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Implication

Retrospective study compares neurological and functional outcomes in patients with ischemic stroke treated with tenecteplase or alteplase, suggesting both are viable options.

Abstract Number: Esoc2026a2442 Tenecteplase Versus Alteplase in Acute Ischemic Stroke: A Real-World Comparative Study

Discussion

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Implication

Key Points

Cite This Study

Abstract Number: Esoc2026a2442 Tenecteplase Versus Alteplase in Acute Ischemic Stroke: A Real-World Comparative Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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